2016 Ramsay: Research Team 1 Update



From solve ME/CFS Initiative.


Dr. Jarred Younger (University of Alabama at Birmingham) recently provided Solve ME/CFS Initiative (SMCI) with a progress update on the Ramsay 2016 Research Team 1 project. Dr. Younger is using a magnetic resonance spectroscopic thermometry (MRSt) technique to assess absolute temperature across the entire brain. He aims to describe inflammatory processes at work in the brains of individuals with ME/CFS. In the following interview, he reflects on what motivated him to study neuroinflammation in ME/CFS and how pilot grants like the Ramsay Award can jump-start promising lines of investigation.

Research update from Dr. Younger

“We are testing the hypothesis that ME/CFS fatigue is due to inflammation of the brain. To test that hypothesis, we are using a type of MRI scan called magnetic resonance spectroscopic imaging (MRSI). This technique allows us to collect 3D, full-brain pictures of several markers that are elevated with brain inflammation. We can measure myo-inositol and choline, which are increased when brain immune cells are activated and lactate which is increased during more severe brain inflammation. The picture below shows an example of an ME/CFS participant, where we can see possible inflammation near the front part of the brain.


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Link to ME Research story

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