By Cort Johnson in Health Rising.
Mackay A, Tate WP. A compromised paraventricular nucleus with a dysfunctional hypothalamus: a novel neuro-inflammatory paradigm for ME/CFS. Int J Immunopathol Pharmacol. 2018:32:1-8.
The HPA’s nexus in two important systems – the stress response and the immune system, both of which almost everyone believes are impaired in ME/CFS – make it an obvious choice for study. The Mackay-Tate hypothesis, though, is unique in that it focuses on a dysfunction in one particular part of one part of the HPA axis – the paraventricular nucleus, in the hypothalamus. It also, notably, links problems in the HPA axis with one of the hottest topics in ME/CFS – neuroinflammation.
They believe their hypothesis could account for just about everything that happens in these diseases.
The Limbic Center
The heart of the neuroinflammatory matter in ME/CFS, they believe, is the limbic system – a primordial part of the brain packed between the brainstem and upper parts of the brain. Its name refers to the fact that it’s located at the limbus (the border) of the brain.
In 2011, Mackay joined Professor Warren Tate’s laboratory in the biochemistry department of the University of Otago, Dunedin, New Zealand. New Zealand is a small country – less than 5 million people – but it’s used to punching above its weight. It’s got the best rugby team in the world, and appears to have actually eliminated the COVID-19 virus. On the ME/CFS side, it’s got Warren Tate, Rosamund Vallings, has been publishing exercise studies, and now here comes Angus Mackay.
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