Are Intranasal Drugs The Future For ME/CFS And Fibromyalgia ?


By Cort Johnson in Health Rising.


The neuroinflammation findings in chronic fatigue syndrome (ME/CFS) and fibromyalagia (FM), while restricted to a few studies, are still pretty compelling. We know that many, if not all of the symptoms associated with ME/CFS and FM such as fatigue, pain, cognitive problems, and mood issues can be produced by the brain.

But how to treat the brain? Getting compounds into the brain is not easy. For one thing, when taken orally they must enter into the general circulation, get broken down by the liver, and then surmount the blood-brain barrier (BBB) – a circuitous route.

There may be an easier route. The brain’s only direct contact with the outside world comes through the nose. There’s no blood-brain barrier to worry about. Anyone with a bloody nose has direct experience of how well vascularized the nose is. Plus, stimuli from the nose don’t go through a peripheral nerve intermediary as do all other stimuli – they shoot straight into the brain.


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