Deconditioning Does Not Explain Orthostatic Intolerance In ME/CFS (Myalgic Encephalomyelitis/Ehronic Fatigue Syndrome)

From the Journal of Translational Medicine.

Abstract

Background

Orthostatic intolerance (OI) is a frequent finding in individuals with myalgic encephalomyelitis /chronic fatigue syndrome (ME/CFS). Published studies have proposed that deconditioning is an important pathophysiological mechanism in various forms of OI, including postural orthostatic tachycardia syndrome (POTS), however conflicting opinions exist. Deconditioning can be classified objectively using the predicted peak oxygen consumption (VO2) values from cardiopulmonary exercise testing (CPET). Therefore, if deconditioning is an important contributor to OI symptomatology, one would expect a relation between the degree of reduction in peak VO2during CPET and the degree of reduction in CBF during head-up tilt testing (HUT).

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https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02819-0

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