Differences So Clear

Suzanne Vernon

 

New Research Brings Clear Differences to Light in ME/CFS
by Suzanne D. Vernon, PhD  |  BHC Research Liaison

 

From The Bateman Horne Center.

 

There is a great song in the musical RENT titled “Seasons of Love” in which they sing about the number of minutes in a year. As I am reviewing and writing this summary of the recent paper, “Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)”, I can’t help but sing it…

 “Five hundred twenty-five thousand six hundred minutes

Five hundred twenty-five thousand moments so dear

Five hundred twenty-five thousand six hundred minutes

How do you measure, measure a year?

 

This song has impact. Maybe because it’s a big number, or because it’s precise, or because we don’t normally think of a year in minutes.  Whatever the reason, it is an enduring anthem that I have stuck in my head. Here’s my rendition related to this research

“Twelve thousand six hundred and eight methylated sites

Twelve thousand six hundred and eight differences oh dear

Twelve thousand six hundred and eight methylated sites

How do you measure, differences so clear?”

 

That’s right … 12,608 differences on the DNA between ME/CFS patients compared to matched healthy people.  That’s a big biological difference.  That’s what Wilfred de Vega, a PhD student in Dr. Patrick McGowan’s laboratory, detected in a paper published in the open access journal BMC Medical Genomics titled, “Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)”.  These differences on the DNA also affect immune cell function.

 

To read the rest of this story, click on the link below:

 

Link to ME Story

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