GABA and Glutamate in Fibromyalgia and Chronic Fatigue Syndrome

Human head and brain. Different kind of waveforms produced by brain activity shown on background. Digital illustration.


By Adrienne Dellwo in Very Well Health.


GABA and glutamate are neurotransmitters—chemical messengers in your brain. One is calming, one is stimulating, and they’re supposed to stay in balance with each other. So what happens if this balance is thrown off?​

Some research suggests an imbalance of these two substances may play a role in fibromyalgia (FMS). Research is less solid on their involvement in chronic fatigue syndrome (ME/CFS), with some studies turning up evidence of dysregulation and others finding nothing.


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