GABA & Glutamate In Fibromyalgia & Chronic Fatigue Syndrome

Brain anatomy  - cross section


GABA and glutamate are neurotransmitters—chemical messengers in your brain. One is calming, one is stimulating, and they’re supposed to stay in balance with each other. So what happens if this balance is thrown off?

Some research suggests an imbalance of these two substances may play a role in fibromyalgia (FMS). Research is less solid on their involvement in chronic fatigue syndrome (ME/CFS), with some studies turning up evidence of dysregulation and others finding nothing.

In Your Brain

The human brain is incredibly complex. Each neurotransmitter performs a variety of functions, and they interact with each other and your neurons (brain cells) in an intricate manner that we don’t fully understand.

Still, we’re constantly learning more about the brain and researchers have been able to link certain neurotransmitter abnormalities to certain illnesses or symptoms. They’ve also found ways to change neurotransmitter function and can see the very real effects it has on research subjects.


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