Molecules May Convert Acute Infection Into ME

Me Australia




By Sasha Nimmo in ME Australia. 

A paper published in Metabolic Brain Disease by Morris, Maes, Burk and Puri suggests Myalgic Encephalomyelitis develops because of genes responsible for immune responses. Their paper discusses how molecules may convert an acute infection into a state of escalating chronic systemic inflammation.

Morris and Maes have written extensively about chronic fatigue syndrome and Myalgic Encephalomyelitis. Morris is an independent researcher and Maes is affiliated with Thailand’s Chungalongkorn University (previously associated with Australia’s Deakin University). In 2015 Maes proposed a new name, case definition and biomarkers: Neuro-Inflammatory and Oxidative Fatigue.

In ‘Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?‘,  the authors lay out an explanatory model of illness development and progression, commencing with a proposed mechanism explaining the development of chronic systemic inflammation, oxidative and nitrosative stress (I&ONS) following a pathogen invasion in genetically predisposed individuals.


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