By Richard N. Podell, M.D., MPH in Open Medicine Foundation.
Patients with ME/CFS or Fibromyalgia (FM) struggle with mental “fog”. We don’t understand why and there’s been little research on why it happens or what to do.
The Mild Cognitive Impairment or MCI of ageing is a different kind of cognitive “fog”. MCI confronts 5-20% of Americans, aged 65 and older. The risk is higher among people who have a high blood level of the amino acid homocysteine. High homocysteine and MCI both predicts a higher risk for developing full- fledged Alzheimer’s Disease.
We know how to reduce homocysteine with a relatively simple nutritional formula. To test whether a homocysteine lowering B vitamin complex mighty improve cognition for people with MCI, medical researchers in the United Kingdom recruited 266 people aged 70 and over, who had relatively mild problems with basic cognitive skills. This study of vitamins and cognition is known as the VITACOG study. Half the subjects were treated with a daily oral pill containing a moderate oral dose of vitamin B12 (500 micrograms), folic acid (800 micrograms) and vitamin B6 (20 mgs). The control group took a daily placebo. Several forms of cognitive testing were done prior to treatment and again several times during the two years of study.
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