New Research Discovers Evidence Of Atypical & Classical ME/CFS


Brain anatomy - cross section


From The Microbe Discovery Project


This latest research is the first to report evidence differentiating Atypical and Classical ME/CFS

The researchers measured 51 different cytokines (immune messenger molecules) in cerebrospinal fluid. Their immune network analysis of these cytokines provided evidence that Atypical and Classical cases of ME/CFS have differing immune signatures within the central nervous system. This work suggests distinct presentations and course of disease for these different subgroups or phenotypes.

The new research paper; ‘Immune network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome with atypical and classical presentations’ has been published in the Nature Publishing Group journal, Translational Psychiatry.

This work is a further continuation of collaborative work on cerebrospinal fluid and cognitive dysfunction by scientists at Columbia University Center for Infection and Immunity (CII) and Simmaron Research.


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