From Syndrome A.
To recap from the previous blog post “Part I: Blood Flow in Sepsis & ME/CFS”, ME/CFS looks like a lot like sepsis and sepsis is an inflammatory illness of blood vessels. The blood vessel problems in sepsis interfere with oxygen delivery to cells.
The particular kind of blood flow problem that you find in sepsis is often described as “heterogeneous perfusion.” In heterogeneous perfusion, blood flow is normal through some capillaries, but in neighboring capillaries, blood flow might be slowed or stopped.
In both ME/CFS and sepsis, we say that there is a problem with “oxygen extraction.” Cells have trouble accessing and using oxygen from the blood to make energy. Heterogeneous perfusion is known to cause problems with oxygen extraction.
Glycocalyx, an important material that lines the inside of blood vessels, is destroyed during sepsis and destruction of glycocalyx leads to heterogeneous perfusion.
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