BY SIMON MCGRATH in ME/CFS Research Review.
It is remarkable that four independent groups have now found that a factor in the blood can affect cell metabolism/mitochondria in ME/CFS and transfer the effect to healthy cells. Here is a summary of the provisional findings.
Fluge & Mella.
The first to find the effect were Dr Oystein Fluge and Professor Olav Mella in 2016.
They were studying energy production in the cell, a logical thing to do when trying to understand an illness where energy is in such short supply.
Cells have two ways to convert food molecules into usable energy. Glycolysis is a process in the cell cytoplasm that extracts a small amount of energy from carbohydrate molecules, producing lactic acid. But the real houses of energy production are mitochondria, which burn up food molecules with oxygen, producing large amounts of usable fuel.
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