ME Research

This Is Personal: BHC’s Patient-First Perspective

Bateman Horne Center

  By Rachel Black in The Batema Horne Center.   Bateman Horne Center is guided by a board of directors that is intimately connected to ME/CFS and FM. Many have sons, daughters or are themselves managing an illness that has taken much of their life away. The Horne in Bateman Horne Most of you know that our […]

The Gut Microbiota At The Intersection Of Diet And Human Health

Gut

  By Christopher L. Gentile, Tiffany L. Weir et al in Science.   Abstract Diet affects multiple facets of human health and is inextricably linked to chronic metabolic conditions such as obesity, type 2 diabetes, and cardiovascular disease. Dietary nutrients are essential not only for human health but also for the health and survival of the trillions […]

Trial By Error: How To Avoid Ethical Review

David Tuller

  By David Tuller, DrPH I have written many posts about BMJ Open’s 2011 school absence study, which reported that school absence records could be useful in identifying children with chronic fatigue syndrome. However, for reasons not yet adequately explained, the investigators exempted the study from ethical review on the grounds that it qualified as “service […]

Are “Old” Muscles Holding People With Chronic Fatigue Syndrome (ME/CFS) Down? Plus Tompkins’ Team Promises New Insights

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      By Cort Johnson in Health Rising.   “New data collectively supports the presence of specific critical points in the muscle that are affected by free radicals.” Fulle et. al. A group of pioneering Italian researchers have been studying the muscles of people with ME/CFS – a rather lonely task – for over 15 […]

The Triumph of Eminence-Based Medicine

Research Study

  By Brian Hughes in Not The Science Bit.   Lines are drawn A quarter of a million Britons have been diagnosed with myalgic encephalomyelitis (ME), the condition also known as chronic fatigue syndrome (CFS). ME/CFS is a severe debilitating illness that renders patients either temporarily or perennially immobile. Sufferers will have often led very active lives […]

ME/CFS, Naviaux’s Cell Danger Response And A Nervous System Under Threat

Nervous system

    By Veronique Mead M.D. in Health Rising.   Thanks again to Veronique for providing her intriguing take on chronic fatigue syndrome (ME/CFS). This is one of a series of articles from Health Rising which feature hypotheses created by health care professionals with ME/CFS or who are associated with ME/CFS. (It is a long post – you […]

Graded exercise therapy for myalgic encephalomyelitis/chronic fatigue syndrome is not effective and unsafe. Re-analysis of a Cochrane review

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  By Mark Vink and Alexandra Vink-Niese in Health Psychology Open.   Abstract The analysis of the 2017 Cochrane review reveals flaws, which means that contrary to its findings, there is no evidence that graded exercise therapy is effective. Because of the failure to report harms adequately in the trials covered by the review, it cannot […]

Does The Microbiome And Virome Contribute To Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ?

Microbiome

  By Fiona Newberry, Shen-Yuan Hsieh, […], and Simon R. Carding in  www.ncbi.nlm.nih.gov. Additional article information Abstract Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (ME/CFS) is a disabling and debilitating disease of unknown aetiology. It is a heterogeneous disease characterized by various inflammatory, immune, viral, neurological and endocrine symptoms. Several microbiome studies have described alterations in the […]

Forty-One International Scientists Have Signed A Declaration Supporting Cochrane’s Decision To Withdraw Its Controversial Review Of Exercise Therapy In ME/CFS

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  From Not The Science Bit.   And I’m one of them. This is important not least because of claims appearing over the weekend that Cochrane pulled its controversial review due to pressure from brain-addled trouble-making “patient activitists,” rather than for scientific reasons. Claims that Cochrane had been harassed were made not by Cochrane themselves, but, […]

Could The Brain’s Mast Cells Be Causing Chronic Fatigue Syndrome (ME/CFS) ?

Simmaron

By Cort Johnson in Simmaron Research.   We propose that stimulation of hypothalamic mast cells by environmental neuroimmune pathogenic and stress triggers activates microglia leading to focal inflammation in the brain and disturbed homeostasis.” Theoharides et. al., 2018 Dr. Theoharis Theoharides is an MD and PhD who has published almost 400 papers. A pioneer in […]

The Metabolic Trap Shines During The Symposium On The Molecular Basis Of ME/CFS At Stanford

Cort_Johnson

By Cort Johnson in Health Rising.   If we ask Nature a question and ask it well, Nature answers. Most of the time the answer refutes our hypothesis. This time, Nature didn’t refute the hypothesis. Robert Phair Ron Davis mentioned one of chronic fatigue syndrome’s aces in the hole several times – the chance to […]

Exclusive: Science Journal To Withdraw Chronic Fatigue Review Amid Patient Activist Complaints

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  By Kate Kelland in Reuters. LONDON, Oct 17 (Reuters) – A respected science journal is to withdraw a much-cited review of evidence on an illness known as chronic fatigue syndrome (CFS) amid fierce criticism and pressure from activists and patients. The decision, described by the scientists involved as “disproportionate and poorly justified”, is being […]

Trial By Error: Per Fink In New York

David Tuller

  By David Tuller, DrPH.   Someone uninformed or stupid or maybe both decided to invite Danish physician Per Fink to present at a conference on so-called psychosomatic medicine being held this weekend at Columbia University. Fink—I won’t dignify him by using an honorific–is a scary guy. He should never have been provided with this […]

Immunosignature Analysis Of ME/CFS

Research

  By O. P. Günther et al. in ProHealth.com.   A random-sequence peptide microarray can interrogate serum antibodies in a broad, unbiased fashion to generate disease-specific immunosignatures. This approach has been applied to cancer detection, diagnosis of infections, and interrogation of vaccine response. We hypothesized that there is an immunosignature specific to ME/CFS and that […]

A Novel Study From Jax ME/CFS Center On A Human T Cell Subset Involved In Sensing The Microbiome

Microbiome

  From JaxMECFS website.   Jackson Labs ME/CFS Collaborative Center Director Derya Unutmaz and his collaborator and microbiome expert Julia Oh recently published a study in the journal Mucosal Immunology, titled “Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation.” Mucosal-associated invariant T (MAIT) cells are a type of T cell present in […]

Invest In ME Resarch International Conference Week London 2019

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  Invest in ME Research has announced dates for events taking place in London for their International Conference Week in May 2019 on biomedical research into ME (Myalgic Encephalomyelitis). The second Thinking the Future conference for young or early career researchers will be on 28th May 2019. The ninth Biomedical Research into ME Colloquium (BRMEC9) […]

Invasion: The Source Of The Neuroinflammation In Chronic Fatigue Syndrome ?

Cort

  By Cort Johnson in Health Rising.   Breaches in the Barrier   The last article reported that Younger speculated that people with chronic fatigue syndrome (ME/CFS) have an immune-triggered metabolic disorder.  The widespread neuroinflammation found in ME/CFS patients provides a clue, he thinks, to what’s going on. It suggests that immune cells are breaching […]

OMF Conference – The Molecular Basis Of ME/CFS

Research

  From cfspatientadvocate.blogspot.com.   For years I have stayed at the Cardinal Hotel in Palo Alto. This is an old-fashioned California hotel. It has a large, high-ceilinged, tile-floor lobby with fireplace and chandeliers. There is no air-conditioning. Cooling is via ceiling fans, the old fashioned way. Early on the morning of the conference, Saturday September 29, […]

The Disability Defenders: The Workwell Foundation, Chronic Fatigue Syndrome (ME/CFS) And Fibromyalgia

Cort_Johnson

By Cort Johnson.   You don’t need to be a large organization to make a big difference. You simply need to be committed to a field (and producing jaw-dropping results doesn’t hurt either.)  Consisting of three exercise physiologists (one with ME/CFS), a clinical coordinator, and working with one of the top chronic fatigue syndrome (ME/CFS) […]

Cardiopulmonary Exercise Test Methodology For Assessing Exertion Intolerance In ME/CFS

Nervous system

    By Staci Stevens et al. in ProHealth.com.   Background: Concise methodological directions for administration of serial cardiopulmonary exercise testing (CPET) are needed for testing of patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Maximal CPET is used to evaluate the coordinated metabolic, muscular, respiratory and cardiac contributions to energy production in patients with ME/CFS. […]

ME/CFS And Freeze: A Metabolic State Of Hibernation That Is Not In Your Head

Research Study

  By VERONIQUE MEAD, MD, MA in Chronic Illness Trauma Studies.   This post introduces the relationship between chronic fatigue syndrome aka ME/CFS and freeze and similar death-like states such as hibernation. You’ll learn how recently identified metabolic changes are regulated by the autonomic nervous system to cause symptoms. And why they are real and not psychological. […]

The Case For IVIG Treatment In Chronic Fatigue Syndrome (ME/CFS), Fibromyalgia, Small Fiber Neuropathy, And POTS : IVIG#3

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  By Cort Johnson in Health Rising.   “The bottom line is that we should rethink this whole area and encourage proper clinical trials.” Dr. Nancy Klimas This article is the last of a three-part series on IVIG which came out of my attending the 2018 Dysautonomia Conference in Nashville, Tennessee. An IVIG Chronic Fatigue […]

ME And CFS Medical Abnormalities

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    From Paradigmchange.com.   More than 1,000 peer-reviewed articles have been published demonstrating a wide variety of physiological abnormalities in patients with myalgic encephalomyelitis, chronic fatigue syndrome and ME/CFS. To read the citations and a brief description of each article, please click on the topic links below. The full abstract for each article can […]

Autoimmune Model Proposes Chronic Fatigue Syndrome (ME/CFS) Begins In The Gut

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    By Cort Johnson in Simmaron Research.   Jonas Blomberg’s paper “Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model” was published in “Frontiers in Immunology”, an apt journal for a paper featuring an “explanatory model” of chronic fatigue syndrome (ME/CFS). Autoimmunity is definitely a new “frontier”; as Blomberg points out, it’s possibility […]

If The Government Won’t Take ME Seriously Who Will ?

Nervous System

  By Lesley Scott in Third Force News.   What happens to patients’ rights when there is no accountability in the system? Myalgic encephalomyelitis (ME) is categorised by the World Health Organisation under diseases of the nervous system. The Scottish Government supports this categorisation and it underpins the current Scottish good practice statement on ME. […]

‘Your Disease Is Real’: Breakthrough In Diagnosis Of Chronic Fatigue Syndrome

Research

  By Nkayla Afshariyan in abc.net.au. There’s been a major breakthrough for people living with chronic fatigue syndrome, with new research into the causation of the disease undercovering it’s a pathological illness. Researchers found chronic fatigue syndrome and the related myalgic encephalomyelitis, or ME, is a calcium ion channel impairment condition. For those who are living with […]

The Heart Of ME/CFS ? Lipkin’s Collaborative Probes The Impact Of Exertion

Dr Ian Lipkin

  BY Simon McGrath in ME/CFS Research Review   The hallmark symptom of ME/CFS is post-exertional malaise (PEM), a prolonged, grim and disproportionate response to exertion. While Dr W. Ian Lipkin’s NIH-funded Collaborative – the Center for Solutions for ME/CFS – is focusing primarily on how problems in patients’ gut microbiomes might drive the disease, his team is also […]

New Insights into Exercise Intolerance And Medication

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  By Rachel Black in Bateman Horne Center.   The Bateman Horne Center is always excited to share important research on ME/CFS and FM happening around the globe. Today, we focus on David Systrom, a pulmonary and critical care physician who researches all forms of exercise intolerance and heads, by request of the Massachusetts General Hospital, the Invasive […]

Significant Association Of DNA Variants With Self-Reported ME/CFS

Research

  By Professor Chris Ponting and colleagues in ME/CFS Research Review.   Summary A new analysis using data from UK Biobank indicates that one version of a particular gene increases the risk of ME/CFS in women. The gene codes for a transporter protein in the mitochondrial membrane and plays a critical role in the urea cycle, […]

System Reset ? Study Suggests Pro-Inflammatory / Autoimmune Reset Occurred In Chronic Fatigue Syndrome (ME/CFS)

Genes

  By Cort Johnson in Simmaron Research.   Epigenetics research holds the fascinating possibility of figuring out what shifted at the very beginning of chronic fatigue syndrome (ME/CFS).  For many with ME/CFS a sudden change occurred – some sort of biological reset quickly happened – which never relinquished itself. Finding out what “reset” occurred is […]

The Heart Of ME/CFS ? Lipkin’s Collaborative Probes The Impact Of Exertion

Dr Ian Lipkin

    By Simon McGrath in ME/CFS Research Review.   The hallmark symptom of ME/CFS is post-exertional malaise (PEM), a prolonged, grim and disproportionate response to exertion. While Dr W. Ian Lipkin’s NIH-funded Collaborative – the Center for Solutions for ME/CFS – is focusing primarily on how problems in patients’ gut microbiomes might drive the disease, his […]

Multidisciplinary Rehabilitation Treatment Is Not Effective For Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Review Of The FatiGo Trial

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  By Mark Vink and Alexandra Vink-Niese in Health Psychology Open. Abstract The FatiGo trial concluded that multidisciplinary rehabilitation treatment is more effective for chronic fatigue syndrome/myalgic encephalomyelitis in the long term than cognitive behaviour therapy and that multidisciplinary rehabilitation treatment is more cost-effective for fatigue and cognitive behaviour therapy for quality of life. However, FatiGo suffered from a […]

Study Finds Reduced Ability To Respond To Energy Demands In ME Patients’ Immune Systems

NK Cells

  By Sasha Nimmo in ME Australia.   Scientists from Australia’s Griffith University found ‘a significant reduction of glycolytic reserve in resting natural killer (NK) cells’ from people with Myalgic Encephalomyelitis (ICC ME) compared with healthy controls. “These findings suggest resting NK cells from ME/CFS patients have reduced ability to increase glycolytic flux to respond […]

The RCCX Hypothesis: Could It Help Explain Chronic Fatigue Syndrome (ME/CFS), Fibromyalgia And Other Diseases ?

Genetics

  By Remy in Health Rising.   The RCCX hypothesis blog by Remy is the third in a series of blogs by Health Rising which highlight hypotheses produced by health care professionals which attempt to shed a new light on the chronic fatigue syndrome / fibromyalgia spectrum of diseases. Chronic illness is exploding in modern […]

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