Welcome to the Twenty-Eighth Emerge Australia Media and Research Digest!
The fortnightly summary of research and media about Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)
1 – Post-exertional malaise Is associated with hypermetabolism, hypoacetylation and purine metabolism deregulation in ME/CFS cases
Authors: McGregor N., Armstrong, C., Lewis, D., & Gooley P.
Post-exertional malaise (PEM) is the primary symptom of ME/CFS. In this study, Australian researchers examined biomarkers of ME/CFS patients after a PEM episode for a period of 7 days and compared these to those of healthy controls. This is a complex paper, analysing changes in biochemistry.
Results showed a fall in hypoxanthine, a purine metabolite, was associated with PEM severity. “This decrease correlated with alterations in the glucose:lactate ratio highly suggestive of a glycolytic anomaly.” Glycolysis is the energy production pathway in the body which converts glucose into usable energy.
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