The Exercise Intolerance In POTS, ME/CFS And Fibromyalgia Explained?



By Cort Johnson in Health Rising.


It’s always  encouraging to see established researchers from outside the chronic fatigue syndrome (ME/CFS) and fibromyalgia fields converging on them. David Systrom, a pulmonologist at Brigham and Women’s hospital in Boston, has been interested in idiopathic or unexplained exercise intolerance for at least a decade.

He and Oldham recently published their magnus opus on exercise intolerance; a study employing over six hundred patients that stretches back nine years.

Unexplained exertional dyspnea caused by low ventricular filling pressures: results from clinical invasivecardiopulmonary exercise testing. William M. Oldham,1,2,3 Gregory D. Lewis,3,4 Alexander R. Opotowsky,2,3,5 Aaron B. Waxman,1,2,3 David M. Systrom1,2,3. Pulm Circ 2016;6(1):55-62. DOI: 10.1086/685054.

In it they proposed that a significant subset of patients with exercise intolerance and heart abnormalities have simply slipped through the cracks.  No diagnosis has been able to explain their low energy production (VO2 max) during exercise; they don’t have heart failure or arrythmia or cystic fibrosis or known mitochondrial problems. Aside from telling them that they’re deconditioned or depressed the medical profession hasn’t known what to do with these patients.


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Link to Exercise Intolerance article

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