Understanding The Metabolic Changes Of B Cell Subsets Throughout Maturation

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By Fane Mensah PhD Student, University College London in Sparrho.

 

I have developed different assays to measure the metabolic activity of B cells throughout maturation

B cells or B lymphocytes are a type of white blood cell (immune cell) that plays a very important role in our humoral immunity. They are most famously known for the production of different types of antibodies that combat pathogens and or infected cells, but they are also vital in assisting other immune cells. During my PhD project, I have developed different assays to measure the metabolic activity of different B cell subsets.

This is very important to understand how different energy pathways link up with different B cell functions. Interestingly, B cell dysfunction has been suggested in a condition known as Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (ME/CFS). ME/CFS is a heterogeneous disease of unknown aetiology without an established diagnostic test. The condition is characterised by fatigue, cognitive impairment and post-exertional malaise after mental or physical exertion lasting for at least 6 months.

 

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