Beyond Bones: The Relevance Of Variants Of Connective Tissue (Hypermobility) To Fibromyalgia, ME/CFS And Controversies Surrounding Diagnostic Classification: An Observational Study

By Jessica A Eccles et al in RCP Journals.


Background Fibromyalgia and myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) are poorly understood conditions with overlapping symptoms, fuelling debate as to whether they are manifestations of the same spectrum or separate entities. Both are associated with hypermobility, but this remains significantly undiagnosed, despite impact on quality of life.

Objective We planned to understand the relevance of hypermobility to symptoms in fibromyalgia and ME/CFS.

Method Sixty-three patient participants presented with a confirmed diagnosis of fibromyalgia and/or ME/CFS; 24 participants were healthy controls. Patients were assessed for symptomatic hypermobility.

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