Does The Microbiome And Virome Contribute To Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ?

Microbiome

 

By Fiona Newberry, Shen-Yuan Hsieh, […], and Simon R. Carding in  www.ncbi.nlm.nih.gov.

Additional article information

Abstract

Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (ME/CFS) is a disabling and debilitating disease of unknown aetiology. It is a heterogeneous disease characterized by various inflammatory, immune, viral, neurological and endocrine symptoms. Several microbiome studies have described alterations in the bacterial component of the microbiome (dysbiosis) consistent with a possible role in disease development. However, in focusing on the bacterial components of the microbiome, these studies have neglected the viral constituent known as the virome. Viruses, particularly those infecting bacteria (bacteriophages), have the potential to alter the function and structure of the microbiome via gene transfer and host lysis.

Viral-induced microbiome changes can directly and indirectly influence host health and disease. The contribution of viruses towards disease pathogenesis is therefore an important area for research in ME/CFS. Recent advancements in sequencing technology and bioinformatics now allow more comprehensive and inclusive investigations of human microbiomes.

To read the rest of this story,click on the link below:

 

 

Link to ME Research story

Leave a Reply

The York ME Community © 2015
Powered by Live Score & Live Score App