Dysregulation Of The Kennedy Pathway And Tricarboxylic Acid Cycle In Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

From Doctors With M.E.

Doctors with M.E. Honorary Fellows, Dr. Lucinda Bateman, Professor Anthony Komaroff and Professor Ian Lipkin continue investigations into ME with co-authorship of newly published research that gives further support to findings of altered metabolomic profiles in ME/CFS patients.

The levels of metabolites altered in these profiles highlight the interconnected nature of ME/CFS pathophysiology, and enable identification of two potentially significant abnormalities that may shed light on causes behind fatigue and cognitive dysfunction.

“Here we report confirmation of decreased levels of phospholipids, including phosphatidylcholine and sphingolipids, and provide evidence for dysregulation of the Kennedy pathway and the tricarboxylic acid cycle.” 

“Our findings provide potential insights into the pathobiology of clinical features of ME/CFS by providing a mechanistic framework for understanding compromised energy production, loss of integrity of cellular and mitochondrial membranes, inflammation, impaired cognition, dysregulated autonomic function, impediments to repair of tissue injury, and redox imbalance.”

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