From ME International.

Some of these links refer to ME/CFS as per the IOM which is a broad criteria encompassing many patients who may not have ME as defined by the ICC.  For choosing proper research candidates, the IC Primer states on page ii: “…the ICC [International Consensus Criteria] select patients who exhibit explicit multi-systemic neuropathology, and have a pathological low threshold of physical and mental fatigability in response to exertion.”

ME patients who exceed the safe activity threshold have post-exertional neuroimmune exhaustion (PENE) which can lead to serious deterioration.

Graded Exercise Therapy (GET) is contraindicated** in anyone with ME.
**something (such as a symptom or condition) that makes a particular treatment or procedure inadvisable.

To read more, click on the link below:

Link to Dangers Of Graded Exercise Therapy story