Hypothesis Predicts Major Failure Point In Chronic Fatigue Syndrome (ME/CFS)

By Cort Johnson in Health Rising.

After attempting to explain the cardiovascular issues in ME/CFS, Klaus Wirth and Carmen Scheibenbogen take on the energy and muscle issues. Warning – this is complex!

Klaus Wirth and Carmen Scheibenbogen brought the chronic fatigue syndrome (ME/CFS) world something entirely new in 2020 with their hypothesis paper, “A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors”.

They proposed that two factors – sympathetic nervous system hyperactivity and ß2AdR receptor problems – are knocking the blood vessels of people with ME/CFS for a loop. As sympathetic nervous system hyperactivity is giving them a good squeeze, the ß2AdR receptors which are supposed to open them up are getting hammered by the immune system.

That leaves the blood vessels unable to deliver the proper amounts of blood to the muscles, brain, organs, etc. The body, of course, can’t have that and so it attempts to fix the situation by releasing vasodilators like bradykinin and prostaglandins.

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