Marijuana As Medicine For ME/CFS And/Or Fibromyalgia Pt I: The Science Behind Cannabis

Health Rising


By Amber Ella in Health Rising.


This is Part I of a three-part series on using marijuana or cannabis as medicine for chronic fatigue syndrome (ME/CFS) and/or fibromaylgia (FM). The first two parts by Amber focus on the science behind using Cannabis and how to get started on it. The last part by Cort focuses on using CBD oils.


  • Cannabis plants contain compounds that mimic those produced by our own endocannabinoid system (ECS).
  • ME/CFS research suggests that an endocannabinoid deficiency may play a role in the disease, at least in women.
  • Cannabis – especially THC – decreases many pro-inflammatory cytokines and increases some anti-inflammatory cytokines.
  • Both THC and CBD help to limit mast cell degranulation, a problem that many individuals with ME/CFS and Ehlers Danlos Syndrome experience.
  • Cannabis is most effective at treating neuropathic pain and can help reduce the amount of opioid painkillers used to treat pain.
  • A second article explores how to get started with Cannabis to treat the many symptoms of ME/CFS.


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