From The Quadram Institute.
Myalgic Encephalomyelitis (ME), also known as Chronic Fatigue Syndrome (CFS), is a severely debilitating condition that is thought to affect up to 250,000 people in the UK. Symptoms include widespread pain, extreme tiredness and an inability to concentrate.
The causes of ME/CFS aren’t known, and there are no effective treatments. Symptoms range in severity, and there are no easily identifiable biomarkers of the condition, so diagnosis is sometimes difficult. There is a pressing need for biomedical research into ME/CFS, and within the Quadram Institute and the wider Norwich Research Park we have the interdisciplinary expertise needed to better understand this complex disease.
Our research builds on recent evidence that ME/CFS has a basis in the immune system. Our focus is on the interactions between the immune system and the microbiota in the gut. Many ME sufferers also have gut-related conditions and several studies have recorded altered microbiota communities.
The gut is a major focal point of the body’s immune system. It must deal with a constant barrage of potentially harmful microbes taken into the body with our food, whilst also supporting a large community of microbes that benefit health – the microbiota. Part of the Quadram Institute’s mission is to understand how this balance is maintained, and how changes in this balance lead to diseased states. One aspect of this includes the study of what happens when the lining of the gut, the intestinal epithelium, fails to act as a barrier and members of the microbiota are able to cross. This is known as leaky gut syndrome and may be important in a number of conditions, including ME/CFS, as it abnormally presents microbes to the immune system and potentially triggering an autoimmune response. With partners at UCL, we are looking at the nature of autoimmune reaction in patients with ME.
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