Postexersion ‘Crash’, Not Fatigue Per Se, Marks Syndrome




By Miriam B Tucker in Metscape.


Fort Lauderdale, FL — New research focused on the phenomenon of postexertional malaise (PEM) is shedding light on the etiology of the illness that has been known as chronic fatigue syndrome, but is now increasingly termed myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

A growing body of evidence, including new findings presented here at the recent International Association for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (IACFSME) research and clinical conference, suggests ME/CFS arises from a complex neuroinflammatory process affecting the brain, autonomic nervous system, and energy metabolism, involving oxidative and nitrosative stress.

The name “chronic fatigue syndrome” is being phased out not just because it is viewed as trivializing a condition that renders many patients completely or nearly bedbound but also because it gives the misleading impression that the illness is characterized simply by prolonged unexplained fatigue. In fact, ME/CFS is characterized by multiple heterogeneous symptoms, with PEM, often described as a “crash” or a significant worsening of already-present symptoms, being a near-universal experience.


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