Researchers Review Melatonin’s Therapeutic Potential For Mitochondrial Dysfunction-Related Diseases




By Alice Meloa in Mitochondria Disease News.

Researchers from the Shahrekord University of Medical Sciences, in Iran presented the most recent findings of the clinical effects of the hormone melatonin on the development of diseases related to mitochondrial dysfunction, such as diabetes, cancer, gastrointestinal diseases, and conditions related to brain function.

The review study, “Melatonin and human mitochondrial diseases,” was published in the Journal of Research in Medical Sciences.

Mitochondria, often called the energy powerhouses of cells, are essential for cells to work properly due in great part to their essential role in energy production. However, this energy production is associated with the development of reactive oxygen species (ROS) or oxidative species.

When mitochondria are dysfunctional, in many cases due to genetic mutations, it can lead to oxidative imbalance and an accumulation of ROS, a process called oxidative stress. This can cause damage to organs, tissues, and various cells in the brain, heart, and vascular system.


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