Value Of Circulating Cytokine Profiling During Submaximal Exercise Testing In ME/CFS



From Solve ME/CFS Initiative.


Cytokines are a broad category of proteins that are important in immune cell signaling and the regulation of inflammation. Numerous studies have found evidence of disrupted cytokine profiles in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), implicating the immune system and inflammation in the pathophysiology of the disease. However, findings between study groups have lacked consistency.

Clarity around the involvement of specific immune system components remains elusive, but a new exercise study in Scientific Reports titled “Value of circulating cytokine profiling during submaximal exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome”. This study provides further evidence for immune dysfunction in ME/CFS and highlights the utility of an exercise protocol in analyzing the disease.


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